The legendary talk show host, 66, announced her businessman partner, 69, has to stay in their guesthouse because he took a number of flights recently.
Oprah laid down the law when Stedman – who she's been with for over 30 years – queried what precautions they should be taking after his trip.
"I was like, 'You ain't coming in here and sleeping in my bed. It doesn't work that way'," she told Oprah Magazine in an Instagram Live interview.
"He's at the guesthouse, because you all know I had pneumonia late last year… I had just gotten off antibiotics last week, because I had a bronchial infection."
She explained he was "one of those" who were "late to the party" about the global pandemic.
He arrived from Chicago on Thursday after speaking in St Louis, so had been on multiple planes.
Most governments around the globe have advised against non-essential travel.
Last year Oprah was forced to cancel all her work after being diagnosed with a "very serious" case of pneumonia.
While she thought it was the common cold following a trip overseas, she eventually had to go to the emergency room.
Speaking on the Ellen DeGeneres show in September last year, she said: "Pneumonia is nothing to play with, y'all.
"It is very serious. I was on antibiotics for a week and the antibiotics weren't working. And then I go back for another CT scan and they go, 'It's actually worse. You should see a lung specialist.'"
Meanwhile, a health expert has warned "millions could die" if Donald Trump lifts the coronavirus lockdowns early.
Tom Inglesby, of the Johns Hopkins Center for Health Security, made the comments a day after the president said he would reconsider America's social distancing rules amid the COVID-19 outbreak.
Despite the President's instinct to protect the US economy, Inglesby wrote: "COVID would spread widely, rapidly, terribly, could kill potentially millions in the year ahead with huge social and economic impact across the country."
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